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Male sexual dysfunction is one of the most common health problems affecting men and is more common with increasing age. Chronic ED affects about 5% of men in their 40s and 15-25% of men by the age of 65. Transient ED and inadequate erection affect as many as 50% of men between the ages of 40 and 70. In around 95% of the cases, a suitable treatment can be found. Erectile dysfunction is treatable at any age, and awareness of this fact has been growing. More men have been seeking help and returning to normal sexual activity because of improved, successful treatments for erectile dysfunction. Viagra, Levitra and Cialis Currently, there are three oral medications approved by the Food and Drug Administration (FDA) for the treatment of erectile dysfunction: sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis). All these agents block the enzyme phosphodiesterase type 5 (PDE-5) and belong to a class of drugs called phosphodiesterase (PDE) inhibitors. Viagra was the first and is probably the most famous of the three PDE-5 inhibitors used to treat erectile dysfunction. Viagra was approved as an effective agent for treating erectile dysfunction in March 27, 1998. Viagra is manufactured by Pfizer, Inc. Levitra was the second PDE-5 inhibitor to come to market in the United States, and it was approved by the FDA in August 19, 2003. Levitra is manufactured by Bayer Pharmaceuticals Corporation. Cialis was the third PDE-5 inhibitor to come to market and was approved by the FDA at the end of November 21, 2003. Cialis is manufactured by Lilly ICOS LLC. The major advantage of PDE-5 inhibitors is that they do not cause an erection at inappropriate times, because they act only in response to sexual stimulation. If there is no sexual stimulation drug remains in the background. All three are taken orally prior to planned sexual activity, acting to increase blood flow in the penis in response to sexual stimulation. However, there are important differences between the three, differences that could influence safety, specificity, duration of action, adverse effects, and ultimately, public acceptance within this class of drug. Mechanism of Action PDE-5 inhibitors do not directly cause an erection of the penis, but they alter the body's response to sexual stimulation by enhancing the effect of the nitric oxide, a chemical that is normally released during stimulation. Nitric oxide causes relaxation of the muscles in the penis, which allows for better blood flow to the penile area. Effectiveness of PDE-5 Inhibitors All 3 PDE-5 inhibitors have demonstrated excellent efficacy. Viagra, at 84%, is slightly more effective than Cialis at 81% and Levitra at 80%. Pharmaceutical Forms, Onset of Action and Duration of Effect Viagra and Levitra differ only minimally in terms of their structure, while Cialis differs markedly from Viagra and Levitra in terms of its molecular structure, which is also reflected in pharmacokinetic differences. Viagra: 25 mg, 50 mg 100 mg tablets Onset of action: 30 minutes (effect delayed if taken with food) Duration of action: 4 to 5 hours Levitra: 2.5 mg, 5 mg, 10 mg, 20 mg tablets Onset of action: 25 minutes (effect delayed by fatty meal) Duration of action: 4 to 5 hours Cialis: 5 mg, 10 mg, 20 mg tablets Onset of action: 16-45 minutes (effect NOT delayed by food) Duration of action: 36 hours All three drugs require sexual stimulation to be effective. Viagra should be taken on an empty stomach it works better if you do not eat a high-fat meal around the time you take it. Levitra may be slightly less effective if you eat a high-fat meal, but a moderate-fat meal does not reduce its effectiveness. Cialis works without regard to what you eat. Viagra and Levitra have similar half-lives, and onset and duration of action. Cialis has a slower onset of action and longer duration of action, which is attributed to its longer half-life. Patients who wish for spontaneity may opt for Cialis, which may allow for successful intercourse up to 36 hours postdose, even though it takes longer to reach peak effect. The considerably longer duration of effect for Cialis will likely allow less frequent dosing and greater impulsiveness between partners, but also could potentially prolong adverse effects. Dosage The recommended dose for Viagra is 50 mg, and the physician may adjust this dose to 100 mg or 25 mg, depending on the patient. The recommended dose for either Levitra or Cialis is 10 mg, and the physician may adjust this dose to 20 mg if 10 mg is insufficient. A lower dose of 5 mg is available for patients who take other medicines or have conditions that may decrease the body's ability to use the drug. Levitra is also available in a 2.5 mg dose. None of these PDE-5 inhibitors should be used more than once a day. Possible Side Effects Although all three drugs are generally well tolerated, side effects are still possible. Most common side effects: Viagra: facial flushing, headache, indigestion Levitra: facial flushing, headache Cialis: headache, indigestion Less Common Side Effects: Viagra: altered vision, dizziness, nasal, congestion Levitra: indigestion, nausea, dizziness, nasal congestion Cialis: back pain, muscle aches, nasal congestion, facial flushing, dizziness Precautions and Contraindications All PDE-5 inhibitors are absolutely contraindicated in persons who take organic nitrates. Alpha-blockers Viagra has precautionary labeling advising against taking 50 mg or 100 mg doses within four hours of taking a alpha-blocker. 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THE RESPIRATORY SYSTEM Intake of oxygen and removal of carbon dioxide are the primary functions of the respiratory system. The respiratory system carries out these life-sustaining acts in close coordination with the circulatory system. Most of the time, we remain blissfully unaware of these automatic functions. The respiratory organs deliver oxygen to the circulatory system. The circulatory system transports the oxygen to all body cells. Oxygen is used by cells to liberate the energy needed for cellular activities. The respiratory system also removes carbon dioxide. Thus, the circulatory system prevents the buildup of this lethal waste byproduct in the body tissues. Irreversible damage to tissues can occur if the respiratory system is halted even for a few minutes. This can cause failure of all the other body systems. The consequence is death! NOSE COMMENCES THE RESPIRATORY PROCESS The respiratory system begins from the nose. It ends in the lungs. The respiratory system is broadly divided into two parts, viz., the upper and the lower respiratory tracts. The upper respirator tract is made up of the nose and the throat (pharynx). The lower respiratory tract includes five organs. They are the voice box (larynx), and the windpipe (trachea), bronchi, bronchioles and the lungs. The trachea splits into the two branches called bronchi. The bronchi further gets divided into further smaller branches called bronchioles. The lungs are a pair of spongy saclike organs. The bronchioles, bronchi, trachea, larynx, pharynx and the nose transport air to and from the lungs. It is the lungs that interact with the circulatory system for delivering oxygen and removing carbon dioxide from the lungs. THE RESPIRATION PROCESS Respiration is a two-pronged process. It involves the respiratory and the circulatory systems. Respiration connotes the coordinated functioning whereby the cells are delivered oxygen and the lethal carbon dioxide is removed. The first phase: The nose begins the first phase of respiration. This is done with inhaling or inhalation (breathing in). The process brings in air along with oxygen from outside the body into the lungs. From the lungs, oxygen goes via the blood vessels to the heart. The heart pumps the oxygen-rich blood to all parts of the body. The first phase of respiration ends with the oxygen moving into the cells from the bloodstream. The second phase: The second phase commences after the oxygen gets into the cells. The cells use the oxygen to produce energy. This independent process is called cellular respiration. It produces the byproduct -- carbon dioxide. The accumulated carbon dioxide now moves from the cells to the bloodstream. Next, the bloodstream transports the carbon dioxide to the heart. Then, the carbon dioxide-laden blood is pumped back to the lungs. The third phase: Again the nose comes into picture during this stage. The lungs push the byproduct to the nose from where it is exhaled or breathed out. This is the final or the third stage when the body gets rid of the carbon dioxide. At the end of the third stage or the entire respiratory cycle another one starts automatically. OTHER FUNCTIONS OF THE RESPIRATORY SYSTEM The respiratory system further regulates the balance of acid and base in tissues. This balancing act is crucial for the normal functioning of cells. It protects the body against disease-causing organisms and toxic substances inhaled with air. The respiratory system also houses the cells that detect smell. Moreover, the respiratory system assists in the production of sounds for speech. THE OLFACTORY NERVE The brownish olfactory nerve is also called olfactory receptors. The olfactory nerve inside the nose is the main nerve of smell. The olfactory region is made up of thick nasal soft mucous membrane. Its brownish color is because of a pigment. The olfactory nerve ends in minute varicose fibers (several small branches). These fibers ultimately conclude in the epithelial cells. Mentionably, the epithelial cells project into the nasal free surface. The olfactory nerve is the first to know of any chemicals that may enter the nasal passages. The receptors immediately trigger off a signal to the brain. This creates the smell perception. THE ESOPHAGUS Esophagus is a muscular tube. The esophagus carries food from the throat to the stomach. The esophagus and the pharynx situated behind the mouth swallow the food and move it to the stomach. The stomach temporarily stores the food, mixes it with digestive juices, and carries out some digestion. The esophagus also holds the stomach contents in place. Actually, this function is carried out by the lower esophageal sphincter. This sphincter is a muscle. It is located at the lower end of the esophagus. THE PHARYNX The pharynx is a passageway for both air and food. The pharynx connects the nose and mouth with the windpipe (trachea) and the food pipe (esophagus). The pharynx is a muscular tube. The pharynx is located within the neck. The pharynx is lined with a mucous membrane. The pharynx is approximately five inches (13 cm) in length. The pharynx lies in the front of the spinal column. The upper portion of the pharynx is known as nasopharynx. The name arises as it begins in the back of the nasal cavity.. The lower part is oropharynx. It points to that area in the back of the mouth. The pharynx ends at the epiglottis. Epiglottis is a flap of cartilage. Epiglottis prevents food from entering the trachea. However, the epiglottis allows the food to enter the esophagus. Two eustachian tubes connect the pharynx to the middle ear. These eustachian equalizes the eardrums air pressure. The pharynx can be infected via the mouth as well as the nose. Sore throat involves pharynx infection (pharyngitis) or throat inflammation. Pharyngitis can be due to infectious mononucleosis, herpes, and viral infections. The viral infections are German measles (rubella), influenza, and common cold. It can also be caused by bacteria like staphylococcal, streptococcal, chlamydial, and diphtherial. These bacteria multiply cause sore throat by multiplying rapidly within the pharynx. Tonsils and Adenoids Among the adults the pharynx contains the tonsils, while among the children the pharynx contains the adenoids. Tonsils: Tonsils are lymphoid tissues at the back of the throat. Tonsils form a tissue ring around the pharynx or the throat. Tonsils are cells. Tonsils are similar to the bloodstream lymphocytes. Tonsils are embedded in fibrous connective tissues. Tonsils are covered by a single epithelium layer. The lymphoid cells are phagocytic. The cells protect the pharynx from bacteria that can cause diseases. Tonsils may become inflamed and chronically or acutely infected. This condition is called tonsillitis. It is generally caused by streptococcus infection. During tonsillitis and streptococcal, the tissues surrounding the tonsils form pus. Then a whitish coat forms over the tonsils which can appear as white specks. This state is called quinsy. When the pharyngeal tonsils become inflamed they become abnormally large. They are called adenoids. Acute cases of tonsillitis are often treated by antibiotics like penicillin. Chronic recurrent tonsillitis may be treated by tonsillectomy (surgical removal of the tonsils). Adenoids: Adenoids are lymphoid tissue at the back of the throat. Adenoids usually shrink and disappear by adolescence. Enlargement of this tissue is common among children. Such a state can interfere with breathing. Symptoms of enlarged adenoids include restless sleep, snoring, breathing via mouth, and a nasal voice. Earlier, these tissues were removed in children. It was thought that inflamed adenoids led to recurrent colds and infections. Nowadays, this condition is recognized as benign. As a result, there are lesser adenoidectomies. THE LARYNX From the pharynx, the inhaled air moves to the larynx. The larynx is about five inches (13 cm) in length. The larynx is located in the central part of the neck. The larynx is made up of several layers of flexible but tough cartilage, a tissue. Mentionably, during puberty the males experience a protrusion of the cartilage. This enlarged prominent extension at the neck is called the Adam’s apple. FUNCTIONS OF THE LARYNX The larynx primarily transports air to the wind pipe (trachea). Besides, the larynx also helps in producing the sounds. The epiglottis -- a leaflike thin tissue portion of the larynx -- further prevents the food from entering the trachea (thus obviating the possibility of choking). Moreover, the cilia cells as well as the mucous membrane of the larynx also filter air. The cilia cells take the airborne substances towards the pharynx where they are swallowed. The epiglottis: The epiglottis stem is attached to the top and the front portions of the larynx. When the epiglottis remains in a vertical position, it acts like a trap door. This happens during the breathing process. But as a person starts swallowing, a reflexive action forces the epiglottis and the larynx to move near each other toward each other. This coming closer of the epiglottis and the larynx forms a protective seal. As a result, the fluids and food are specifically sent towards the food pipe (esophagus). When the reflexive action doesn’t work: What happens when the reflexive action doesn’t function is that the food can enter the larynx. This happens when one eats the meal fats or when one laughs while swallowing. The result is that there will be a recurrent cough impelled choking effect. At times this apparently simple choking effect can even be life-threatening. The cough is the body’s reflexive action to clear the larynx of the impediment. Whenever such choking takes place, someone must thump the back portion between the shoulder blades several times. This will help the person to get over the choking effect. The Heimlich maneuver: The Heimlich maneuver clears the windpipe of obstructions like food or fluid. The first-aid providing person applies thrusts in quick and in upward motion at the patient’s abdomen. The objective is to expel the object stuck at the trachea (windpipe). Standing behind the victim, the person keeps both his arms across the patient’s waist. Then, he places the fist of one hand below the rib cage and a bit above the navel. All the while, he keeps the thumb against the patient’s body. He uses the other hand for holding the fist and for applying pressure. Next, he puts quick pressure on the abdomen. The pressure is put in an inward and an upward motion. This fast recurrent action forces the lung air to get rid of the substance blocking the windpipe. However, in cases where the patient cannot stand still, is overweight, faints following the choking effect, the Heimlich maneuver is done in a different manner. The patient is made to lie face down. The first-aid provider carries on the process with the heel of a hand. Important: Nonetheless, it is important that the person does not put undue pressure on the rib cage. This is especially true when the patient is a child or an elderly person. Too much pressure can break ribs. Pertaining to pregnant woman or overweight people, the first-aid provider must place his hands only on the lower half of the breastbone (sternum) while carrying out the maneuver. In acute choking, tracheotomy (a surgical procedure) is undertaken to carry out bypass of the larynx. This operation brings in air to the trachea. TRACHEA, BRONCHI, AND BRONCHIOLES The trachea is another tube measuring approximately six inches (15 cm). The trachea is located below the larynx. From the larynx the air passes on to the trachea. About 20 sturdy C-shaped cartilage rings constitute the trachea. These rings help to keep the trachea open. In the process, air gets transported unhindered. While the unfastened cartilage is located at the trachea’s back portion, their ends are linked to each other by muscle tissues. Bronchi & bronchioles: The trachea base is situated at the portion where the neck meets the body trunk. At this juncture, the trachea splits into the right and the left bronchi. These bronchi transport air to the right and left lungs respectively. Inside the lungs, these bronchi again break up into smaller tubes -- the bronchioles. In fact, the respiratory system’s cleansing process is carried out by those bronchioles that are situated at the initial part, bronchi, and the trachea. These organs carry out the cleansing process via the mucous membrane linings as well as the ciliated cells. These cilia and the lining push the mucus upward towards the pharynx. 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